Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development

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Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development.

Dorsal spinal cord neurons receive and integrate somatosensory information provided by neurons located in dorsal root ganglia. Here we demonstrate that dorsal spinal neurons require the Krüppel-C(2)H(2) zinc-finger transcription factor Bcl11a for terminal differentiation and morphogenesis. The disrupted differentiation of dorsal spinal neurons observed in Bcl11a mutant mice interferes with thei...

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Neuronal intrinsic properties shape naturally evoked sensory inputs in the dorsal horn of the spinal cord

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The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord

Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific laminae and different transcription factors are involved in their specification. The murine homeodomain Gbx1 protein is expressed in the mantle zone of the spinal cord at E12.5-13.5, correlating with the appearance of a discernable dorsal horn around E1...

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ژورنال

عنوان ژورنال: Development

سال: 2012

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.072850